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AZTTP - Azidothymidine triphosphate, Zidovudine triphosphate

(3'-Azido-3'-deoxythymidine-5'-triphosphate, Azidothymidine-5'-triphosphate, 3'-Azido-2',3'-dideoxythymidine-5'-Triphosphate, 3'-Azido-ddTTP)

Azidothymidine triphosphate is available as the tetra-triethylammonium salt in 1mg, 5 mg and 10 mg quantities. For a quotation for larger quantities or for a custom synthesis of any nucleoside mono, di or triphosphate, please inquire.

Purity: 95+ %

Supplied as an aqueous solution at pH 7+. Concentration is written on the label.

Orders can be placed by credit card using the add-to-cart button below, or by telephone or online for a purchase order.

AZTTP (3'-Azido-3'-deoxythymidine-5'-triphosphate)
$93/1mg (1.1 µmole)
$455/5mg (5.5 µmole)
$837/10mg (11 µmole)
Purchase amount:
The 2D structure of the free acid form of Azidothymidine triphosphate (AZTTP) is:

Chemical structure of AZTTP also known as Azidothymidine triphosphate or zidovudine triphosphate
Selected references:

Nomura et al. Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system. Redox Biol. 2017 Oct;13:407-417.

Chen et al. Biphasic elimination of tenofovir diphosphate and nonlinear pharmacokinetics of zidovudine triphosphate in a microdosing study. J Acquir Immune Defic Syndr. 2012 Dec 15;61(5):593-9.

Roucairol et al. Design, synthesis and studies of triphosphate analogues for the production of anti AZT-TP antibodies. Bioorg Med Chem Lett. 2010 Feb 1;20(3):987-90.

Aweeka et al. AIDS Clinical Trials Group 5092s Study Team. Pharmacokinetic evaluation of the effects of ribavirin on zidovudine triphosphate formation: ACTG 5092s Study Team. HIV Med. 2007 Jul;8(5):288-94. Erratum in: HIV Med. 2007 Sep;8(6):412.

Hillaireau et al. Hybrid polymer nanocapsules enhance in vitro delivery of azidothymidine-triphosphate to macrophages. J Control Release. 2006 Dec 1;116(3):346-52. Epub 2006 Oct 3.

Hillaireau et al. Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules. Int J Pharm. 2006 Oct 31;324(1):37-42. Epub 2006 Jul 10.

Meléndez et al. Lack of evidence for in vivo transformation of zidovudine triphosphate to stavudine triphosphate in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 2006 Mar;50(3):835-40.

King et al. Quantitation of zidovudine triphosphate concentrations from human peripheral blood mononuclear cells by anion exchange solid phase extraction and liquid chromatography-tandem mass spectroscopy; an indirect quantitation methodology. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 2;831(1-2):248-57. Epub 2006 Jan 10.

Akeb et al. The production and evaluation of antibodies for enzyme immunoassay of AZTTP. Nucleosides Nucleotides Nucleic Acids. 2001 Mar;20(3):243-50.

Fletcher et al. Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons. AIDS. 2000 Sep 29;14(14):2137-44.

Font et al. Determination of zidovudine triphosphate intracellular concentrations in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals by tandem mass spectrometry. Antimicrob Agents Chemother. 1999 Dec;43(12):2964-8.

Brossette et al. Synthesis of analogues of 5'-mono-, 5'-di-, and 5'-triphosphate-AZT for the development of specific enzyme immunoassay for monitoring of intracellular levels of AZT-MP, AZT-DP, and AZT-TP. Nucleosides Nucleotides. 1999 Apr-May;18(4-5):939-40.

Bloom et al. Azidothymidine triphosphate determination using micellar electrokinetic capillary chromatography. Cell Mol Biol (Noisy-le-grand). 1997 Nov;43(7):1051-5.

Elimadi et al. Differential effects of zidovudine and zidovudine triphosphate on mitochondrial permeability transition and oxidative phosphorylation. Br J Pharmacol. 1997 Aug;121(7):1295-300.

Törnevik et al. Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T-lymphoblastoid cells. Biochem Pharmacol. 1995 Mar 15;49(6):829-37.

Cherrington et al. Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases beta and gamma. Biochem Pharmacol. 1994 Nov 16;48(10):1986-8.

Carroll et al. Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate. Biochemistry. 1994 Mar 1;33(8):2113-20.

Robbins et al. Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells. Antimicrob Agents Chemother. 1994 Jan;38(1):115-21. PubMed PMID: 7511360;

Pokholok et al. Interactions of the HIV-1 reverse transcriptase 'AZT-resistant' mutant with substrates and AZT-TP. FEBS Lett. 1993 Jul 5;325(3):237-41.

Chen et al. Selective action of 4'-azidothymidine triphosphate on reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases alpha and beta. Biochemistry. 1993 Jun 15;32(23):6002-10. .

Nickelet al. Interactions of azidothymidine triphosphate with the cellular DNA polymerases alpha, delta, and epsilon and with DNA primase. J Biol Chem. 1992 Jan 15;267(2):848-54.

Heidenreich et al. Inhibition of human immunodeficiency virus 1 reverse transcriptase by 3'-azidothymidine triphosphate. Eur J Biochem. 1990 Sep 24;192(3):621-5.

König et al. Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type 1 reverse transcriptase and DNA polymerase gamma. Antimicrob Agents Chemother. 1989 Dec;33(12):2109-14. PubMed PMID: 2482702;

Reimer et al. Effects of suramin, HPA-23 and 3'-azidothymidine triphosphate on the reverse transcriptase of bovine leukaemia virus. Acta Virol. 1989 Jan;33(1):43-9.

Balzarini et al. Alpha, beta- and beta, gamma-methylene 5'-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine-5'-triphosphate. Correlation between affinity for reverse transcriptase, susceptibility to hydrolysis by phosphodiesterases and anti-retrovirus activity. Biochem Pharmacol. 1988 Jun 15;37(12):2395-403.